Priv.-Doz. Dr. med. Markus Hufnagel, DTM&H

Dr. Markus Hufnagel is a specialist in pediatric and adolescent medicine, infectious diseases, pediatric rheumatology, immunology, tropical medicine, travel medicine and vaccinology.

As Director of the Pediatric Outpatient Clinic at the University Children's Hospital in Freiburg, Germany, he is responsible for patient care and care management, medical teaching and medical research. His current research focuses on antibiotic resistance and infections with gram-positive pathogens. Active in numerous international projects, Dr. Hufnagel regularly collaborates with European and North American partners, as well as with several NGOs working in resource-poor countries.

Professional Experience

2010 – Present	• Attending Physician ("Oberarzt"), Director of Pediatric Outpatient Clinic • Associate Professor of Pediatric and Adolescent Medicine • Infectious Diseases Specialist, (Board Certified) • Pediatric Rheumatologist, (Board Certified) • Lecturer in Immunology, Vaccinology, Tropical Medicine,Travel Medicine and Pediatric Rheumatology University Children’s Hospital, Freiburg, Germany
2009	Acting Attending Physician ("Funktionsoberarzt"); Specialist and Lecturer in Pediatric Infectious Diseases, Tropical Medicine, Travel Medicine, Vaccinology, Immunology and Rheumatology University Children’s Hospital, Freiburg, Germany
2007 – 2008	Senior Physician and Lecturer, Specialist in Pediatric Infectious Diseases, and Pediatric Rheumatology Fellow University Children’s Hospital, Freiburg, Germany
Apr – May 2007	Tropical Medicine Fellow Swiss Tropical Institute, Basel, Switzerland
2005 – 2007	Senior Physician, Pediatric Infectious Diseases Fellow, and Lecturer in Pediatric Infectious Diseases and Rheumatology University Children’s Hospital, Freiburg, Germany
2003 – 2005	Pediatric Resident and Assistant Director in Pediatric Infectious Diseases and Rheumatology University Children’s Hospital, Kiel, Germany
2000 – 2003	Research Fellow in Microbiology of Infectious Diseases Channing Laboratory, Dept. of Microbiology and Molecular Genetics, Brigham & Women's Hospital, Dept. of Medicine, Harvard Medical School, Boston, Mass., USA
1995 – 2000	Pediatric Resident and Assistant in Pediatric Infectious Diseases & Rheumatology University Children’s Hospital, Kiel, Germany
1994	Research Fellow in Immunology of Infectious Diseases Max-Planck-Institute for Immunobiology, Freiburg, Germany
1992 – 1994	Physician in Training ("Arzt im Praktikum") University Children’s Hospital, Freiburg, Germany

International Visiting Lectureships

Nov 2011	Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine Angkor Hospital for Children, Siem Reap, Cambodia & The Lake Clinic, Tonle Sap, Cambodia
July 2011	Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine Universitas Hasanuddin in Makassar, Sulawesi, Indonesia
Mar 2010	Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine Universitas Unsyiah Kuala in Banda Aceh, Sumatra, Indonesia & Universitas Gadjah Mada in Yogyakarta, Java, Indonesia
Dec 2008	Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine Angkor Hospital for Children, Siem Reap, Cambodia

Education, Training & Degrees

2010	Board Certification as Pediatric Rheumatologist ("Zusatzweiterbildung")
2009	Board Certification as Physician for Infectious Diseases ("Zusatzweiterbildung")
2009	Certification of PhD Degree Equivalency and Associate Professor Status, PhD in Bacterial Immunology (in accordance with official U.S. guidelines)
2009	Postdoctoral Medical Teaching Degree ("Habilitation") Albert-Ludwig University, Freiburg, Germany
2009	Good Clinical Practice (GCP) Training Certification Mainz, Germany
2007	Certification as Pediatric Infectious Disease Specialist Accreditation according to the Curriculum of the European Union of Medical Specialists (UEMS), Confederation of European Specialists in Paediatrics (CESP), and the European Society for Paediatric Infectious Diseases (ESPID)
2005	Board Certification as Physician for Pediatrics and Adolescent Medicine ("Facharzt")
1995	Diploma Course and License in Tropical Medicine and Hygiene London School of Hygiene & Tropical Medicine, London, England
1994	Approval of Medical Doctoral Thesis ("Promotion") Albert-Ludwig University, Freiburg, Germany
1994	Medical License ("Approbation als Arzt")
1992	Medical Certification ("Medizinisches Staatsexamen")
1984 – 1992	Medical School, Study of Human Medicine • Friedrich-Alexander University, Erlangen, Germany • Albert-Ludwig University, Freiburg, Germany • University of Basel, Basel, Switzerland • University of Cape Town, Cape Town, South Africa

Grants & Fellowships

2011	European Society for Paediatric Infectious Diseases (ESPID) Funding for Post-Graduate Teaching Visit to a Resource-Poor Country Teaching visits to the Angkor Hospital for Children, Siem Reap, Cambodia, and to The Lake Clinic, Tonle Sap, Cambodia
2011	German Academic Exchange Service (Deutscher Akademischer Austausch Dienst - DAAD) Travel Grant to participate as a Lecturer at the Mother and Child Health Summer School Makassar, Indonesia
2010	German Academic Exchange Service (Deutscher Akademischer Austausch Dienst - DAAD) Travel Grant to participate as a Lecturer at the Tropical Medicine, Infectious Diseases and Molecular Biology Summer School Banda Aceh & Yogyakarta, Indonesia
2008	European Society for Paediatric Infectious Diseases (ESPID) Funding for Post-Graduate Teaching Visit to a Resource-Poor Country Teaching visit to the Angkor Hospital for Children, Siem Reap, Cambodia
2005	German Society for Pediatric Infectious Diseases (DGPI) Fellowship Grant "Pediatric Infectious Diseases" For a two-year fellowship at the University Children's Hospital, Freiburg, Germany
1999	"Walter-Marget Vereinigung zur Förderung der Infektiologie" Research Fellowship Grant For an infectious diseases fellowship at the Channing Laboratory, Harvard Medical School, Boston, MA

Professional Memberships

Original Published Research

Jakob A, Creutzfeldt R, Staszewski O, Winterpacht A, Berner R, Hufnagel M (2012)
Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Pädiatrie, (on press)

Farmand S, Henneke P, Hufnagel M, Berner R (2012)
Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre.
European Journal of Clinical Microbiology and Infectious Diseases, (on press)
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Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Gräff A, Aichele P, zur Stadt U, Schwarz K, Ehl S (2011)
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Blood, 118:4620-4629
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Fluegge K, Wons J, Spellerberg B, Swoboda S, Siedler A, Hufnagel M, Berner R (2011)
Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate.
Pediatric Infectious Disease Journal, 30:1027-1031
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Afshar B, Broughton K, Creti R, Detcheva A, Hufnagel M, Kriz P, Lambertsen L, Lovgren M, Melin P, Orefici G, Poyart C, Radtke A, Rodriguez-Granger J, Skov Sørensen UB, Telford J, Valinsky L, Zachariadou L, Members of the DEVANI study group, Efstratiou A. (2011)
International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci).
Journal of Clinical Microbiology, 49:1475-1482
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Maul-Pavicic A, Chiang S, Rensing-Ehl A, Fauriat C, Hufnagel M, Schulze I, Bass T, Schamel W, Schwarz K, Bryceson Y, Ehl S (2011)
Orai1 is required for target cell-induced NK cell degranulation and cytokine production.
Proceedings of the National Academy of Science, 108:3324-3329
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Schenk T, Maier B, Hufnagel M, Strahm B, Kontny U, Neumann-Haefelin D, Falcone V (2011)
Persistence of HBoV in immunocompromised patients.
Pediatric Infectious Diseases Journal, 30:82-84
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Hatz C, Inoubli S, Loutan L, Genton B, Behrens R, Hufnagel M (2010)
Japanese encephalitis: Risk for endemic populations and for travellers. [Encéphalite japonaise: risque pour les populations vivant en zones d'endémie et pour les voyageurs.]
Revue Médicale Suisse, 6(248):956-9. French.
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Carlsson G, Hufnagel M, Jansen O, Claviez A, Nabavi A (2010)
Rapid recovery of motor and cognitive functions after resection of a right frontal lobe meningioma in a child.
Child's Nervous System, 26:105-111
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Hatz C, Werlein J, Mutsch M, Hufnagel M, Behrens RH (2009)
Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland.
Journal of Travel Medicine, 16:200-203
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von Schnakenburg C, Hufnagel M, Superti-Furga A, Rieger-Fackeldey E, Berner R (2009)
Successful Continuous Renal Replacement Therapy in a Neonate with Early-onset Group B Streptococcal Sepsis and Multi-organ Dysfunction Syndrome. [Multiorganversagen bei Early-onset-B-Streptokokkensepsis: Erfolgreicher Einsatz einer kontinuierlichen venovenösen Hämofiltration (CVVH) beim Neugeborenen.]
Klinische Pädiatrie, 221:251-3. German.
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Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008)
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics, 167:1149-59
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Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007)
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases, 7:107
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Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007)
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases, 13:1425-1427
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Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006)
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection, 34:22-25
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Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006)
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell, 124:287-299
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Hufnagel M, Czech N, Schmidt M, Hero B, Claviez A (2006)
Neuroblastoma Stage 4S with 123I-MIBG-positive bone marrow involvement.
Pediatric Blood & Cancer, 46:264-265
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Hufnagel M, Huebner J (2005)
Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.
Infection, 33:373-376
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Kropec A, Hufnagel M, Zimmermann K, Huebner J (2005)
In vitro assessment of the host response against Enterococcus faecalis in probiotic preparations.
Infection, 33:377-379
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Hufnagel M, Kropec A, Theilacker C, Huebner J (2005)
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology), 12:930-934
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Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004)
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology, 42:2548-2557
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Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004)
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to
biofilm formation and prolonged bacteremia in mice.
Journal of Infectious Diseases, 189:420-430
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Hufnagel M, Koch S, Kropec A, Huebner J (2003)
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology, 88:263-267
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Lässker U, Harder TC, Hufnagel M, Suttorp M (2002)
Rapid molecular discrimination of infection with wild-type varicella zoster virus or varicella vaccine virus.
Infection, 30:320-322
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Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001)
A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology, 39:4413-4419
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Eichmann D, Hufnagel M, Quick P, Santer R (1999)
Treatment of hyperinsulinemic hypoglycemia with nifedipine.
European Journal of Pediatrics, 158:204-206
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Muller D, Hufnagel M, Suttorp (1999)
Accidental overdose of vancomycin in preterm twins.
Pediatric Infectious Diseases Journal, 18:744-745
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Hufnagel M, Eichmann D, Stieh J, Santer R (1998)
Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy:
a family with documented hyperinsulinemia in two generations.
Journal of Clinical Endocrinology and Metabolism, 83:2215-2216
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Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997)
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria
monocytogenes-infected IFN-gamma receptor-deficient mice.
Journal of Immunology, 158:5297-5304
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Hufnagel M, Niemeyer C, Zimmerhackl LB, Tuchelmann T, Sauter S, Brandis M (1995)
Hemophagocytosis: a complication of acute Q fever in a child.
Clinical Infectious Diseases, 21:1029-1031
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Hufnagel M, Tuchelmann, Zimmerhackl LB, Leititis JU, Tüchelmann T, Brandis M, Brem S, Schindera F (1994)
Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection.
[Akutes Nierenversagen ohne Leberbeteiligung bei Leptospira icterohaemorrhagiae-Infektion.]
Monatsschrift Kinderheilkunde 142:957-960. German.
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Medical Reviews

Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A Orefici G, Poyart C,
Telford J, Efstratiou A, Killian K, Krizova P, Baldassarri L, Spellerberg S, Puertas A and Rosa-Fraile M. (2012)
Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project.
European Journal of Clinical Microbiolology and Infectious Diseases (on press)

Kenzel S, Hufnagel M, Berner R, Henneke P (2010)
Pneumococcus Vaccination and Serotype Replacement: Do we need a new vaccine or vaccination concept? [Pneumokokkenimpfung und Serotyp-Replacement: Brauchen wir ein neues Impf(stoff)konzept?.]
Deutsche Medizinische Wochenschrift 135:1198-1200. German.
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Lander F, Hufnagel M, Berner R (2010)
Antimicrobial therapy for sepsis in pediatrics. [Antimikrobielle Therapie der Sepsis in der Pädiatrie.]
Pädiatrische Praxis 75:233-245. German.

Weih M, Schaller G, Degirmenci U, Hufnagel M, Kornhuber J (2009)
Differential diagnosis of neurodegenerative disorders in young adults.
[Differentialdiagnosen zu neurodegenerativen Erkrankungen im jungen Erwachsenenalter.]
Fortschritte der Neurologie-Psychiatrie 77(11):662-668. German.
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Hufnagel M, Berner R (2009)
Lymphadenitis colli – a guideline for diagnostic and therapeutic procedures.
[Lymphadenitis colli – ein Leitfaden für das diagnostische und therapeutische Vorgehen.]
Kinder- und Jugendarzt, 40:300-11. German.
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Hufnagel M, Henneke P, Krüger M, Berner R (2008)
Severe, rapid-onset sepsis in childhood. [Die foudroyante Sepsis im Kindesalter.]
Up2date Notfallmedizin, 3:149-171. German.
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Hufnagel M, Burger A, Zwigart M, Berner R (2008)
Epidemiology of Staphylococcus aureus bacteremia in childhood – "secular trends."
[Epidemiologie von Staphylococcus aureus-Bakteriämien im Kindesalter – "säkulare Trends."]
Kinder- und Jugendmedizin, 8:88-92. German.
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Hufnagel M, Berner R (2007)
Lice, fleas and other beasts. [Läuse, Flöhe und anderes Getier.]
Kinderkrankenschwester, 26:283-8. German.
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Hufnagel M, Neef V, Berner R (2007)
White tongue in Infants – not always oral thrush. [Die weiße Zunge beim Säugling – nicht immer ein Mundsoor.]
Kinderärztliche Praxis 78:152-154. German.
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Koch S, Hufnagel M, Huebner J (2004)
Treatment and prevention of enterococcal infections – alternative and experimental approaches.
Expert Opinion on Biological Therapy, 4:1519-31
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Koch S, Hufnagel M, Theilacker C, Huebner J (2004)
Enterococcal infections: host response, therapeutic, and prophylactic possibilities.
Vaccine, 22:822–830
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Hufnagel M (2001)
Hand, mouth, foot disease. [Hand-Mund-Fuß-Krankheit.]
Deutsche Medizinische Wochenschrift, 126:1125-1126. German.
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Hufnagel M, Schmitt HJ (1999)
Acute fever in travelers returning from the tropics. [Akutes Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:496-503. German.

Hufnagel M, Schmitt HJ (1999)
Chronic fever in travelers returning from the tropics. [Chronisches Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:504-509. German.

Medical Textbook Contributions

Hufnagel M (2009, 2003, 2000)
Legionella. [Legionellose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 332-5. German.

Hufnagel M (2009, 2003, 2000)
Leptospirosis. [Leptospirose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 344-6. German.

Hufnagel M (2008)
Pneumococcus: The Clinical Picture. [Pneumokokken: Das Krankheitsbild.]
Chapter in "Konjugatimpfstoffe und Infektionskrankheiten durch bekapselte Erreger." [Conjugate Vaccines and Infectious Diseases Caused by Capsulated Microorganisms],
ed. Berner R. Uni-Med Science, 1:25-35. German.
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Schmitt HJ, Hufnagel M (2007, 2003, 2001)
Typhus and Cholera Vaccination. [Typhus- und Choleraschutzimpfung.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 95-96. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Chlamydia Infections. [Chlamydien-Infektionen.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 773-6. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Q-Fever. [Q-Fieber.]
Chapter in "Pädiatrie Grundlagen und Praxis,[Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 798-9. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Sepsis
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 739-44. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Toxic Shock Syndrome. [Toxisches Schocksyndrom.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 744-6. German.

Keywords

Pediatrics, Pediatric Medicine, Infectious Diseases, Infectious Disease Specialist, Pediatric Rheumatology, Rheumatologist, Immunology, Tropical Medicine, Travel Medicine, Vaccinology, vaccines, Freiburg, University Clinic, Research
Pädiatrie, pädiatrische Medizin, Kindermedizin, Jugendmedizin, Kinderarzt, Arzt, Infektiologie, Infektiologue, pädiatrische Rheumatologie, Rheumatologue, Immunologie, Tropenmedizin, Reisemedizin, Vakzinologie, Impfungen, Freiburg, Uniklinik, Uniklinikum, Forschung

Contact

Dr. Markus Hufnagel
Center for Pediatrics and Adolescent Medicine, Clinic I
Division of Pediatric Infectious Diseases, Immunology and Vaccinology
University Hospital Freiburg
Mathildenstr. 1
D-79106 Freiburg
Germany

Tel: +49 (0)761-270-43000
Fax: +49 (0)761-270- 44730
Email:
Website: markushufnagel.com

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