[ BACK TO TOP ]

Priv.-Doz. Dr. med. Markus Hufnagel, DTM&H


Dr. Markus Hufnagel
Dr. Markus Hufnagel is a specialist in pediatric and adolescent medicine, infectious diseases, pediatric rheumatology, immunology, tropical medicine, travel medicine and vaccinology.

As Director of the Pediatric Outpatient Clinic at the University Children's Hospital in Freiburg, Germany, he is responsible for patient care and care management, medical teaching and medical research. His current research focuses on antibiotic resistance and infections with gram-positive pathogens. Active in numerous international projects, Dr. Hufnagel regularly collaborates with European and North American partners, as well as with several NGOs working in resource-poor countries.

Professional Experience

2010 – Present

• Attending Physician ("Oberarzt"), Director of Pediatric Outpatient Clinic
• Associate Professor of Pediatric and Adolescent Medicine
• Infectious Diseases Specialist, (Board Certified)
• Pediatric Rheumatologist, (Board Certified)
• Lecturer in Immunology, Vaccinology, Tropical Medicine,Travel Medicine and Pediatric Rheumatology
University Children’s Hospital, Freiburg, Germany

2009

Acting Attending Physician ("Funktionsoberarzt");
Specialist and Lecturer in Pediatric Infectious Diseases, Tropical Medicine,
Travel Medicine, Vaccinology, Immunology and Rheumatology
University Children’s Hospital, Freiburg, Germany

2007 – 2008

Senior Physician and Lecturer, Specialist in Pediatric Infectious Diseases,
and Pediatric Rheumatology Fellow
University Children’s Hospital, Freiburg, Germany

Apr – May 2007

Tropical Medicine Fellow
Swiss Tropical Institute, Basel, Switzerland

2005 – 2007

Senior Physician, Pediatric Infectious Diseases Fellow, and
Lecturer in Pediatric Infectious Diseases and Rheumatology
University Children’s Hospital, Freiburg, Germany

2003 – 2005

Pediatric Resident and Assistant Director in Pediatric Infectious Diseases and Rheumatology
University Children’s Hospital, Kiel, Germany

2000 – 2003

Research Fellow in Microbiology of Infectious Diseases
Channing Laboratory, Dept. of Microbiology and Molecular Genetics,
Brigham & Women's Hospital, Dept. of Medicine,
Harvard Medical School, Boston, Mass., USA

1995 – 2000

Pediatric Resident and Assistant in Pediatric Infectious Diseases & Rheumatology
University Children’s Hospital, Kiel, Germany

1994

Research Fellow in Immunology of Infectious Diseases
Max-Planck-Institute for Immunobiology, Freiburg, Germany

1992 – 1994

Physician in Training ("Arzt im Praktikum")
University Children’s Hospital, Freiburg, Germany


International Visiting Lectureships

Nov 2011

Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine
Angkor Hospital for Children, Siem Reap, Cambodia & The Lake Clinic, Tonle Sap, Cambodia

July 2011

Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine
Universitas Hasanuddin in Makassar, Sulawesi, Indonesia

Mar 2010

Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine
Universitas Unsyiah Kuala in Banda Aceh, Sumatra, Indonesia &
Universitas Gadjah Mada in Yogyakarta, Java, Indonesia

Dec 2008

Visiting Lecturer and Consultant in Pediatric Infectious Diseases / Tropical Medicine
Angkor Hospital for Children, Siem Reap, Cambodia


Education, Training & Degrees

2010

Board Certification as Pediatric Rheumatologist
("Zusatzweiterbildung")

2009

Board Certification as Physician for Infectious Diseases
("Zusatzweiterbildung")

2009

Certification of PhD Degree Equivalency and Associate Professor Status,
PhD in Bacterial Immunology
(in accordance with official U.S. guidelines)

2009

Postdoctoral Medical Teaching Degree ("Habilitation")
Albert-Ludwig University, Freiburg, Germany

2009

Good Clinical Practice (GCP) Training Certification
Mainz, Germany

2007

Certification as Pediatric Infectious Disease Specialist
Accreditation according to the Curriculum of the European Union of Medical Specialists (UEMS), Confederation of European Specialists in Paediatrics (CESP), and the European Society for Paediatric Infectious Diseases (ESPID)

2005

Board Certification as Physician for Pediatrics and Adolescent Medicine ("Facharzt")

1995

Diploma Course and License in Tropical Medicine and Hygiene
London School of Hygiene & Tropical Medicine, London, England

1994

Approval of Medical Doctoral Thesis ("Promotion")
Albert-Ludwig University, Freiburg, Germany

1994

Medical License ("Approbation als Arzt")

1992

Medical Certification ("Medizinisches Staatsexamen")

1984 – 1992

Medical School, Study of Human Medicine
• Friedrich-Alexander University, Erlangen, Germany
• Albert-Ludwig University, Freiburg, Germany
• University of Basel, Basel, Switzerland
• University of Cape Town, Cape Town, South Africa


Grants & Fellowships

2011

European Society for Paediatric Infectious Diseases (ESPID) Funding for Post-Graduate Teaching Visit to a Resource-Poor Country
Teaching visits to the Angkor Hospital for Children, Siem Reap, Cambodia, and
to The Lake Clinic, Tonle Sap, Cambodia

2011

German Academic Exchange Service (Deutscher Akademischer Austausch Dienst - DAAD) Travel Grant to participate as a Lecturer at the Mother and Child Health Summer School
Makassar, Indonesia

2010

German Academic Exchange Service (Deutscher Akademischer Austausch Dienst - DAAD) Travel Grant to participate as a Lecturer at the Tropical Medicine, Infectious Diseases and Molecular Biology Summer School
Banda Aceh & Yogyakarta, Indonesia

2008

European Society for Paediatric Infectious Diseases (ESPID) Funding for Post-Graduate Teaching Visit to a Resource-Poor Country
Teaching visit to the Angkor Hospital for Children, Siem Reap, Cambodia

2005

German Society for Pediatric Infectious Diseases (DGPI) Fellowship Grant "Pediatric Infectious Diseases"
For a two-year fellowship at the University Children's Hospital, Freiburg, Germany

1999

"Walter-Marget Vereinigung zur Förderung der Infektiologie" Research Fellowship Grant
For an infectious diseases fellowship at the Channing Laboratory, Harvard Medical School, Boston, MA


Professional Memberships


Original Published Research

Jakob A, Creutzfeldt R, Staszewski O, Winterpacht A, Berner R, Hufnagel M (2012)
Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Pädiatrie, (on press)

Farmand S, Henneke P, Hufnagel M, Berner R (2012)
Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre.
European Journal of Clinical Microbiology and Infectious Diseases, (on press)
PDF Download Download PDF

Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Gräff A, Aichele P, zur Stadt U, Schwarz K, Ehl S (2011)
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Blood, 118:4620-4629
PDF Download Download PDF

Fluegge K, Wons J, Spellerberg B, Swoboda S, Siedler A, Hufnagel M, Berner R (2011)
Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate.
Pediatric Infectious Disease Journal, 30:1027-1031
PDF Download Download PDF

Afshar B, Broughton K, Creti R, Detcheva A, Hufnagel M, Kriz P, Lambertsen L, Lovgren M, Melin P, Orefici G, Poyart C, Radtke A, Rodriguez-Granger J, Skov Sørensen UB, Telford J, Valinsky L, Zachariadou L, Members of the DEVANI study group, Efstratiou A. (2011)
International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci).
Journal of Clinical Microbiology, 49:1475-1482
PDF Download Download PDF

Maul-Pavicic A, Chiang S, Rensing-Ehl A, Fauriat C, Hufnagel M, Schulze I, Bass T, Schamel W, Schwarz K, Bryceson Y, Ehl S (2011)
Orai1 is required for target cell-induced NK cell degranulation and cytokine production.
Proceedings of the National Academy of Science, 108:3324-3329
PDF Download Download PDF

Schenk T, Maier B, Hufnagel M, Strahm B, Kontny U, Neumann-Haefelin D, Falcone V (2011)
Persistence of HBoV in immunocompromised patients.
Pediatric Infectious Diseases Journal, 30:82-84
PDF Download Download PDF

Hatz C, Inoubli S, Loutan L, Genton B, Behrens R, Hufnagel M (2010)
Japanese encephalitis: Risk for endemic populations and for travellers. [Encéphalite japonaise: risque pour les populations vivant en zones d'endémie et pour les voyageurs.]
Revue Médicale Suisse, 6(248):956-9. French.
PDF Download Download PDF

Carlsson G, Hufnagel M, Jansen O, Claviez A, Nabavi A (2010)
Rapid recovery of motor and cognitive functions after resection of a right frontal lobe meningioma in a child.
Child's Nervous System, 26:105-111
PDF Download Download PDF

Hatz C, Werlein J, Mutsch M, Hufnagel M, Behrens RH (2009)
Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland.
Journal of Travel Medicine, 16:200-203
PDF Download Download PDF

von Schnakenburg C, Hufnagel M, Superti-Furga A, Rieger-Fackeldey E, Berner R (2009)
Successful Continuous Renal Replacement Therapy in a Neonate with Early-onset Group B Streptococcal Sepsis and Multi-organ Dysfunction Syndrome. [Multiorganversagen bei Early-onset-B-Streptokokkensepsis: Erfolgreicher Einsatz einer kontinuierlichen venovenösen Hämofiltration (CVVH) beim Neugeborenen.]
Klinische Pädiatrie, 221:251-3. German.
PDF Download Download PDF

Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008)
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics, 167:1149-59
PDF Download Download PDF

Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007)
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases, 7:107
PDF Download Download PDF

Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007)
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases, 13:1425-1427
PDF Download Download PDF

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006)
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection, 34:22-25
PDF Download Download PDF

Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006)
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell, 124:287-299
PDF Download Download PDF

Hufnagel M, Czech N, Schmidt M, Hero B, Claviez A (2006)
Neuroblastoma Stage 4S with 123I-MIBG-positive bone marrow involvement.
Pediatric Blood & Cancer, 46:264-265
PDF Download Download PDF

Hufnagel M, Huebner J (2005)
Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.
Infection, 33:373-376
PDF Download Download PDF

Kropec A, Hufnagel M, Zimmermann K, Huebner J (2005)
In vitro assessment of the host response against Enterococcus faecalis in probiotic preparations.
Infection, 33:377-379
PDF Download Download PDF

Hufnagel M, Kropec A, Theilacker C, Huebner J (2005)
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology), 12:930-934
PDF Download Download PDF

Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004)
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology, 42:2548-2557
PDF Download Download PDF

Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004)
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to
biofilm formation and prolonged bacteremia in mice.

Journal of Infectious Diseases, 189:420-430
PDF Download Download PDF

Hufnagel M, Koch S, Kropec A, Huebner J (2003)
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology, 88:263-267
PDF Download Download PDF

Lässker U, Harder TC, Hufnagel M, Suttorp M (2002)
Rapid molecular discrimination of infection with wild-type varicella zoster virus or varicella vaccine virus.
Infection, 30:320-322
PDF Download Download PDF

Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001)
A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology, 39:4413-4419
PDF Download Download PDF

Eichmann D, Hufnagel M, Quick P, Santer R (1999)
Treatment of hyperinsulinemic hypoglycemia with nifedipine.
European Journal of Pediatrics, 158:204-206
PDF Download Download PDF

Muller D, Hufnagel M, Suttorp (1999)
Accidental overdose of vancomycin in preterm twins.
Pediatric Infectious Diseases Journal, 18:744-745
PDF Download Download PDF

Hufnagel M, Eichmann D, Stieh J, Santer R (1998)
Further evidence for a dominant form of  familial persistent hyperinsulinemic hypoglycemia of infancy:
a family with documented hyperinsulinemia in two generations.

Journal of Clinical Endocrinology and Metabolism, 83:2215-2216
PDF Download Download PDF

Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997)
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria
monocytogenes-infected IFN-gamma receptor-deficient mice.

Journal of Immunology, 158:5297-5304
PDF Download Download PDF

Hufnagel M, Niemeyer C, Zimmerhackl LB, Tuchelmann T, Sauter S, Brandis M (1995)
Hemophagocytosis: a complication of acute Q fever in a child.
Clinical Infectious Diseases, 21:1029-1031
PDF Download Download PDF

Hufnagel M, Tuchelmann, Zimmerhackl LB, Leititis JU, Tüchelmann T, Brandis M, Brem S, Schindera F (1994)
Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection.
[Akutes Nierenversagen ohne Leberbeteiligung bei Leptospira icterohaemorrhagiae-Infektion.]

Monatsschrift Kinderheilkunde 142:957-960. German.

PDF Download Download PDF


Medical Reviews

Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A Orefici G, Poyart C,
Telford J, Efstratiou A, Killian K, Krizova P, Baldassarri L, Spellerberg S, Puertas A and Rosa-Fraile M. (2012)
Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project.
European Journal of Clinical Microbiolology and Infectious Diseases (on press)

Kenzel S, Hufnagel M, Berner R, Henneke P (2010)
Pneumococcus Vaccination and Serotype Replacement: Do we need a new vaccine or vaccination concept? [Pneumokokkenimpfung und Serotyp-Replacement: Brauchen wir ein neues Impf(stoff)konzept?.]
Deutsche Medizinische Wochenschrift 135:1198-1200. German.
PDF Download Download PDF

Lander F, Hufnagel M, Berner R (2010)
Antimicrobial therapy for sepsis in pediatrics. [Antimikrobielle Therapie der Sepsis in der Pädiatrie.]
Pädiatrische Praxis 75:233-245. German.

Weih M, Schaller G, Degirmenci U, Hufnagel M, Kornhuber J (2009)
Differential diagnosis of neurodegenerative disorders in young adults.
[Differentialdiagnosen zu neurodegenerativen Erkrankungen im jungen Erwachsenenalter.]

Fortschritte der Neurologie-Psychiatrie 77(11):662-668. German.
PDF Download Download PDF

Hufnagel M, Berner R (2009)
Lymphadenitis colli – a guideline for diagnostic and therapeutic procedures.
[Lymphadenitis colli – ein Leitfaden für das diagnostische und therapeutische Vorgehen.]

Kinder- und Jugendarzt, 40:300-11. German.
PDF Download Download PDF

Hufnagel M, Henneke P, Krüger M, Berner R (2008)
Severe, rapid-onset sepsis in childhood. [Die foudroyante Sepsis im Kindesalter.]
Up2date Notfallmedizin, 3:149-171. German.

PDF Download Download PDF

Hufnagel M, Burger A, Zwigart M, Berner R (2008)
Epidemiology of Staphylococcus aureus bacteremia in childhood – "secular trends."
[Epidemiologie von Staphylococcus aureus-Bakteriämien im Kindesalter – "säkulare Trends."]

Kinder- und Jugendmedizin, 8:88-92. German.
PDF Download Download PDF

Hufnagel M, Berner R (2007)
Lice, fleas and other beasts. [Läuse, Flöhe und anderes Getier.]
Kinderkrankenschwester, 26:283-8. German.
PDF Download Download PDF

Hufnagel M, Neef V, Berner R (2007)
White tongue in Infants – not always oral thrush. [Die weiße Zunge beim Säugling – nicht immer ein Mundsoor.]
Kinderärztliche Praxis 78:152-154. German.

PDF Download Download PDF

Koch S, Hufnagel M, Huebner J (2004)
Treatment and prevention of enterococcal infections – alternative and experimental approaches.
Expert Opinion on Biological Therapy, 4:1519-31
PDF Download Download PDF

Koch S, Hufnagel M, Theilacker C, Huebner J (2004)
Enterococcal infections: host response, therapeutic, and prophylactic possibilities.
Vaccine, 22:822–830
PDF Download Download PDF

Hufnagel M (2001)
Hand, mouth, foot disease. [Hand-Mund-Fuß-Krankheit.]
Deutsche Medizinische Wochenschrift, 126:1125-1126. German.
PDF Download Download PDF

Hufnagel M, Schmitt HJ (1999)
Acute fever in travelers returning from the tropics. [Akutes Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:496-503. German.

Hufnagel M, Schmitt HJ (1999)
Chronic fever in travelers returning from the tropics. [Chronisches Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:504-509. German.


Medical Textbook Contributions

Hufnagel M (2009, 2003, 2000)
Legionella. [Legionellose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 332-5. German.

Hufnagel M (2009, 2003, 2000)
Leptospirosis. [Leptospirose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 344-6. German.

Hufnagel M (2008)
Pneumococcus: The Clinical Picture. [Pneumokokken: Das Krankheitsbild.]
Chapter in "Konjugatimpfstoffe und Infektionskrankheiten durch bekapselte Erreger." [Conjugate Vaccines and Infectious Diseases Caused by Capsulated Microorganisms],
ed. Berner R. Uni-Med Science, 1:25-35. German.

PDF Download Download PDF

Schmitt HJ, Hufnagel M (2007, 2003, 2001)
Typhus and Cholera Vaccination. [Typhus- und Choleraschutzimpfung.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 95-96. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Chlamydia Infections. [Chlamydien-Infektionen.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 773-6. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Q-Fever. [Q-Fieber.]
Chapter in "Pädiatrie Grundlagen und Praxis,[Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 798-9. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Sepsis
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 739-44. German.

Hufnagel M, Schmitt HJ (2007, 2003, 2001)
Toxic Shock Syndrome. [Toxisches Schocksyndrom.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Lentze MJ, Schaub J, Schulte FJ, Spranger J. Springer-Verlag Berlin, pp. 744-6. German.


Keywords


Contact

Dr. Markus Hufnagel
Center for Pediatrics and Adolescent Medicine, Clinic I
Division of Pediatric Infectious Diseases, Immunology and Vaccinology
University Hospital Freiburg

Mathildenstr. 1
D-79106 Freiburg
Germany

Tel: +49 (0)761-270-43000
Fax: +49 (0)761-270- 44730
Email:
Website: markushufnagel.com

Impressum