Dr. Markus Hufnagel, MD, DTM&H


Dr; Markus Hufnagel

Contact

Center for Pediatrics and Adolescent Medicine
University Hospital Freiburg
Mathildenstr. 1
D-79106 Freiburg
Germany

Tel: (+49) 761-2704300
Email: markus.hufnagel@uniklinik-freiburg.de



Original Published Research

Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008)
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics (on press)

Hufnagel M, Burger A, Zwigart M, Berner R (2008)
Epidemiologie von Staphylococcus aureus-Bakteriämien im Kindesalter – "säkulare Trends".
Kinder- und Jugendmedizin, 8:88-92
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Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007)
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases, 7:107
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Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007)
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases, 13:1425-1427
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Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006)
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection, 34:22-25
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Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006)
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell, 124:287-299
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Hufnagel M, Czech N, Schmidt M, Hero B, Claviez A (2006)
Neuroblastoma Stage 4S with 123I-MIBG-positive bone marrow involvement.
Pediatric Blood & Cancer, 46:264-265
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Hufnagel M, Huebner J (2005)
Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.
Infection, 33:373-376
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Kropec A, Hufnagel M, Zimmermann K, Huebner J (2005)
In vitro assessment of the host response against Enterococcus faecalis in probiotic preparations.
Infection, 33:377-379
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Hufnagel M, Kropec A, Theilacker C, Huebner J (2005)
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology), 12:930-934
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Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004)
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology, 42:2548-2557
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Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004)
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to biofilm formation and prolonged bacteremia in mice.
Journal of Infectious Diseases, 189:420-430
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Koch S, Hufnagel M, Theilacker C, Huebner J (2004)
Enterococcal infections: host response, therapeutic, and prophylactic possibilities.
Vaccine, 22:822–830
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Hufnagel M, Koch S, Kropec A, Huebner J (2003)
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology, 88:263-267
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Lässker U, Harder TC, Hufnagel M, Suttorp M (2002)
Rapid molecular discrimination of infection with wild-type varicella zoster virus or varicella vaccine virus.
Infection, 30:320-322
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Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001)
A new LightCyclerTM polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology, 39:4413-4419
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Eichmann D, Hufnagel M, Quick P, Santer R (1999)
Treatment of hyperinsulinemic hypoglycemia with nifedipine.
European Journal of Pediatrics, 158:204-206
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Muller D, Hufnagel M, Suttorp (1999)
Accidental overdose of vancomycin in preterm twins.
Pediatric Infectious Diseases Journal, 18:744-745
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Hufnagel M, Eichmann D, Stieh J, Santer R (1998)
Further evidence for a dominant form of  familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations.
Journal of Clinical Endocrinology and Metabolism, 83:2215-2216
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Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997)
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice.
Journal of Immunology, 158:5297-5304
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Hufnagel M, Niemeyer C, Zimmerhackl LB, Tuchelmann T, Sauter S, Brandis M (1995)
Hemophagocytosis: a complication of acute Q fever in a child.
Clinical Infectious Diseases, 21:1029-1031
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Curriculum Vitae

Professional Experience

2007 – Present

Senior Physician, Specialist in Pediatric Infectious Diseases,
Tropical Medicine & Rheumatology, and Lecturer in Pediatric Infectious Diseases, Immunology & Rheumatology
University Children’s Hospital, Freiburg, Germany

2007

Tropical Medicine Fellow
Swiss Tropical Institute, Basel, Switzerland

2005 – 2007

Senior Physician, Pediatric Infectious Diseases Fellow, and
Lecturer in Pediatric Infectious Diseases & Rheumatology
University Children’s Hospital, Freiburg, Germany

2003 – 2005

Pediatric Resident and
Assistant Director in Pediatric Infectious Diseases & Rheumatology

University Children’s Hospital, Kiel, Germany

2000 – 2003

Research Fellow in Microbiology of Infectious Diseases
Harvard Medical School Channing Laboratory and
Brigham & Women’s Hospital, Boston, Mass., USA

1995 – 2000

Pediatric Resident and
Assistant in Pediatric Infectious Diseases & Rheumatology

University Children’s Hospital, Kiel, Germany

1994

Research Fellow in Immunology of Infectious Diseases
Max-Planck-Institute for Immunobiology, Freiburg, Germany

1992 – 1994

Physician in Training („Arzt im Praktikum”)
University Children’s Hospital, Freiburg, Germany

Education & Training

2005

Certification as Physician for Pediatrics and Adolescent Medicine

1995

Diploma Course and Certification in Tropical Medicine and Hygiene
London School of Hygiene & Tropical Medicine, London, England

1994

Approval of Medical Thesis („Promotionsurkunde”)
Albert-Ludwig University, Freiburg, Germany

1994

Medical License („Approbation als Arzt“)

1992

Medical Certification („Medizinisches Staatsexamen“)

1984 – 1992

Medical School, Study of Human Medicine
• Friedrich-Alexander University, Erlangen, Germany
• Albert-Ludwig University, Freiburg, Germany
• University of Basel, Basel, Switzerland
• University of Cape Town, Cape Town, South Africa

Professional Memberships

German Society of Tropical Pediatrics, German Society of Pediatrics and Adolescent Medicine, German Society of Pediatric Rheumatology, German Society of Pediatric Infectious Diseases, European Society of Pediatric Infectious Diseases


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